人类ErbB2转录因子1（ TOB1）基因编码抗增殖蛋白Tob1，属于BTG／TOB蛋白家族，通过Ras／MAPK信号通路，以及与CCR4?Caf1结合形成复合体等多种途径参与调控细胞周期进程，抑制细胞增殖。 TOB1作为抑癌基因与肿瘤发生、发展及转移密切相关，在大多数肿瘤中表达下调，其功能性失活与磷酸化积累及亚细胞分布相关，而且TOB1表达变化还与癌细胞电离辐射的敏感性相关。“,”Transducer of ErbB?2?1 ( TOB1) encodes Tob1 protein which is a member of the BTG/TOB antiproliferative pro?tein family. It is involved in regulating cell cycle progression through Ras/MAPK pathway and forming complex with CCR4?Caf1 to in?hibit cell proliferation. TOB1 as a tumor suppressor gene is closely related with tumor occurrence, development and metastasis. The de?creased expression of Tob1 occurred in the majority of tumor. Its functional inactivation is associated with phosphorylation of accumula?tion and subcellular distribution, and the expression of TOB1 is associated with ionization sensitivity.