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目的探讨双生子人群血压水平、体质指数 (BMI)、空腹血糖水平和各项血脂指标 (总胆固醇、甘油三酯和高密度脂蛋白胆固醇 )的遗传度。方法对山东威海和浙江丽水双生子登记系统注册的双生子 ,在卵性鉴定的基础上 ,以组内相关系数法研究代谢综合征相关指标的遗传度。结果本次调查双生子共 2 6 0双 ,甘油三酯单卵和异卵双胞胎对内方差齐性检验差异无显著性 ,血糖、总胆固醇、高密度脂蛋白胆固醇、收缩压、舒张压、体质指数异卵双生子对内变异大于同卵双生子。估计遗传度 h2 分别为 ,血糖 :0 .4 7,总胆固醇 :0 .34,甘油三酯 :0 .17,高密度脂蛋白胆固醇 :0 .2 6 ,收缩压 :0 .78,舒张压 :0 .6 7,体质指数 :0 .6 4。调整年龄和性别后 ,遗传度 h2 分别是 ,血糖 :0 .5 6 ,总胆固醇 :0 .37,甘油三酯 :0 .18,高密度脂蛋白胆固醇 :0 .2 4 ,收缩压 :0 .96 ,舒张压 :0 .76 ,体质指数 :0 .88。结论在代谢综合征相关性状中 ,血糖、收缩压、舒张压、体质指数可能受遗传因素的影响大于环境因素 ,而总胆固醇、甘油三酯、高密度蛋白胆固醇受遗传影响相对较小。
Objective To investigate the heritability of twins in blood pressure, body mass index (BMI), fasting blood glucose (FBG) and various blood lipid markers (total cholesterol, triglyceride and high density lipoprotein cholesterol). Methods Twins born in Weihai, Shandong and Lishui, Zhejiang were enrolled in this study. The heritability of the related indicators of metabolic syndrome was studied by the correlation coefficient method in the group on the basis of egg identification. Results There were no significant differences in homogeneity of triglyceride monozygotic and fraternal twins between the two pairs of twins in this survey. Blood glucose, total cholesterol, high density lipoprotein cholesterol, systolic blood pressure, diastolic blood pressure, physical constitution The index intraspecific variation is greater than the identical twins. Estimated heritability h2, respectively, blood glucose: 0.47, total cholesterol: 0.34, triglycerides: 0.17, high-density lipoprotein cholesterol: 0.26, systolic blood pressure: 0.78, diastolic blood pressure: 0 .6 7, body mass index: 0.6 6. After adjusting for age and sex, the heritabilities h2 were, respectively, blood glucose: 0.56, total cholesterol: 0.37, triglycerides: 0.18, high density lipoprotein cholesterol: 0.24, systolic blood pressure: 96, diastolic pressure: 0.76, body mass index: 0.88. Conclusion In the metabolic syndrome-related traits, blood glucose, systolic blood pressure, diastolic blood pressure, body mass index may be affected by genetic factors more than environmental factors, while total cholesterol, triglycerides and high-density protein cholesterol are less affected by the genetic factors.