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目的探讨孕中期孕妇产前筛查的临床应用,分析检测中可能的影响因素,以提高检测结果的准确性。方法应用时间分辨免疫荧光分析法检测2009年6月—2011年12月我院就诊的2389例孕14～21周孕妇血清中甲胎蛋白(AFP)、游离人绒毛膜促性腺激素(Free-β-hCG)的浓度,经软件计算风险率。对筛查出的具有胎儿出生缺陷的高风险孕妇,在知情同意且自愿的原则下行羊水穿刺或B超检查进行产前诊断。结果本组2389例筛查出唐氏综合征高风险130例(5.44%),爱德华综合征高风险33例(1.38%),神经管缺陷高风险48例(2.01%)。190例高危标本中产前诊断出18三体综合征1例。结论对孕中期孕妇进行产前筛查,有利于高风险胎儿的及早诊断和治疗,从而降低缺陷儿的出生率。
Objective To explore the clinical application of prenatal screening during the second trimester of pregnancy and to analyze the possible influencing factors in order to improve the accuracy of the test results. Methods The serum levels of AFP, Free-β (Free-β) in 2389 pregnant women with gestational age from 14 to 21 weeks in our hospital from June 2009 to December 2011 were detected by time-resolved immunofluorescence assay. -hCG) concentrations, the software calculates the risk. High-risk pregnant women with fetal birth defects that have been screened for prenatal diagnosis of amniocentesis or B-ultrasound under the terms of informed consent and voluntary consent. Results A total of 2389 cases of this group were screened for 130 cases (5.44%) with high risk of Down’s syndrome, 33 cases (1.38%) with high risk of Edward’s syndrome and 48 cases (2.01%) with high risk of neural tube defects. 190 cases of high-risk specimens in prenatal diagnosis of trisomy 18 in 1 case. Conclusion Prenatal screening of pregnant women during the second trimester is conducive to the early diagnosis and treatment of high risk fetuses, thus reducing the birth rate of defective children.