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目的探讨更昔洛韦治疗小儿流行性腮腺炎合并脑膜炎的临床效果。方法 65例流行性腮腺炎合并脑膜炎患儿,随机分为对照组(32例)和观察组(33例),对照组予以干扰素治疗,观察组采用更昔洛韦治疗,观察两组治疗效果。结果对照组32例患儿中,显效13例,有效12例,无效7例,总有效率78.1%。观察组33例患儿中,显效18例,有效15例,无效0例,总有效率100.0%。观察组总有效率明显高于对照组,差异具有统计学意义(χ~2=8.09,P<0.05)。对照组不良反应发生率为28.1%(9/32),其中发生恶心呕吐3例、腹痛腹泻2例,皮疹、白细胞减少、头痛头晕、肢体乏力各1例;观察组不良反应发生率为6.1%(2/33),其中恶心呕吐、皮疹各1例。观察组不良反应发生率明显低于对照组,差异具有统计学意义(χ~2=5.63,P<0.05)。结论更昔洛韦治疗小儿流行性腮腺炎合并脑膜炎的临床效果突出,具有疗效好、安全性高等优势,值得临床实践中推广应用。
Objective To investigate the clinical effect of ganciclovir on children with mumps and meningitis. Methods Sixty-five children with mumps and meningitis were randomly divided into control group (n = 32) and observation group (n = 33). The control group was treated with interferon, the observation group was treated with ganciclovir, and the two groups were treated effect. Results Among 32 cases of control group, 13 cases were markedly effective, 12 cases were effective, 7 cases were ineffective and the total effective rate was 78.1%. In 33 cases of observation group, 18 cases were markedly effective, 15 cases were effective, 0 was ineffective and the total effective rate was 100.0%. The total effective rate in the observation group was significantly higher than that in the control group, the difference was statistically significant (χ ~ 2 = 8.09, P <0.05). The incidence of adverse reactions in the control group was 28.1% (9/32), of which nausea and vomiting occurred in 3 cases, abdominal pain and diarrhea in 2 cases, rash, leukopenia, headache and dizziness, limb weakness in 1 case; adverse reactions in the observation group was 6.1% (2/33), of which nausea and vomiting, skin rash in 1 case. The incidence of adverse reactions in the observation group was significantly lower than that in the control group, with statistical significance (χ ~ 2 = 5.63, P <0.05). Conclusion Ganciclovir treatment of children with mumps meningitis with prominent clinical results, with good efficacy, high safety, it is worth promoting the clinical practice.