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目的 探讨生殖激素水平在预测早期先兆流产妊娠预后中的价值。方法 采用放射免疫法对 43例早期先兆流产 ,40例正常早孕妇女血 β -HCG ,P ,E2 ,PRL ,FSH ,LH进行测定。结果 先兆流产妊娠失败组血 β -HCG ,P ,E2 含量显著低于对照组和先兆流产妊娠持续组 (P <0 .0 0 1) ,血PRL ,FSH ,LH含量与对照组差异无显著性 (P >0 .0 5 )。如分别取β -HCG 180IU/L ,P 30nmol/L ,E 2 0 .5nmol/L作为阈值 ,对低于阈值者诊断先兆流产预后不良的敏感性分别为 80 % ,80 % ,10 0 % ,特异性为 78% ,74% ,83 % ,总符合率为 79% ,77% ,91%。E2 是最可靠的预测指标。结论 单次测定血 β -HCG ,P ,E2 预测早期先兆流产的妊娠预后是有价值的。
Objective To investigate the value of reproductive hormones in predicting the prognosis of early threatened abortion. Methods The levels of β-HCG, P, E2, PRL, FSH and LH in 43 cases of early threatened abortion and 40 normal pregnant women were measured by radioimmunoassay. Results The levels of serum β -HCG, P and E2 in the failed pregnancy induced by threatened abortion were significantly lower than those in the control group and the threatened abortion (P <0.01), and there was no significant difference in the levels of PRL, FSH and LH in the control group (P> 0.05). For example, 180IU / L β -HCG, 30nmol / L E 2 and 5nmol / L E 2 respectively were used as the threshold value, and the sensitivity of undetectable prognosis of threatened abortion below the threshold were 80%, 80%, 100% The specificity was 78%, 74%, 83%, the total coincidence rate was 79%, 77%, 91%. E2 is the most reliable predictor. Conclusion The single determination of serum β -HCG, P, E2 prognosis of threatened abortion early prognosis of pregnancy is valuable.