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目的 了解嗜麦芽寡养单胞菌的临床分布及耐药特征,为临床合理用药提供依据.方法 用常规方法对2005-2008年本院临床标本进行细菌的培养、分离,用MieWalK 40进行细菌的鉴定,以美国临床实验室标准化研究所推荐的纸片扩散法(K-B法)进行药物敏感性试验,Whonet 5.0进行数据统计.结果 135株嗜麦芽寡养单胞菌主要来自痰占76.3%(103/135),分布以重症监护室(ICU)为主占80.0%(108/135);对6种抗菌药物的敏感率分别为替卡西林/棒酸36.3%、氯霉素57.8%、头孢他啶64.4%、左氧氟沙星75.6%、复方新诺明77.0%及米诺环素100.0%.结论 临床分离的嗜麦芽寡养单胞菌主要来自痰标本,分布以ICU为主,米诺环素、复方新诺明、左氧氟沙星、头孢他啶对嗜麦芽寡养单胞菌具有较好的体外抗菌活性.“,”Objective To study the distribution and resistance of Stenotrophomonas maltophilia in this hospital. Methods Routine microbiological methods were used in the isolation and cultivation of S. maltophilia.Identification of the isolates was performed using the MicWalK-40 all-automatic microbiology analysis system. Antimicrobial susceptibility test was pedormed according to the K-B method as recommended by CLSI. The data were statistically analyzed using Whonet 5.0. Results Most of the S. maltophilia were isolated from the sputum (76.3%) and the samples were mainly obtained from the wards of ICU (80%). Results of the susceptibility test showed that the resistance rate of the bacterial isolates to Ticarcillin/Clavulic Acid, Chloramphencio, Ceftazidime, Sulfadmethoxazole/Trimethoprim, Levofloxacin and Minocycline was 36.3%, 57.8%, 64.4%, 75.6%, 77.0% and 100.0%,respectively. Conclusion Most of the S. maltophilia were isolated from the sputum of patients in ICU. Minocycline, Sulfadmehoxazole/Trimethofim, Levofloxacin and Ceftazidime are the best antibiotics for S. maltophilia.