TLR2是目前已克隆人类TLRs家族中表达范围最广,识别病原微生物及其产物种类最多的分子。它分布于单核细胞、巨噬细胞、中性粒细胞、树突细胞及上皮细胞和肿瘤细胞等,可以在细菌、病毒、真菌及其他一些病原体感染中发挥天然免疫作用,并通过其胞内信号转导而连接获得性免疫。TLR2的表达和免疫应答也受到病原体、激素和细胞因子等的调节。 TLR2 is one of the most widely expressed TLRs in human cloned human families, which recognizes most of the pathogenic microorganisms and their products. It is distributed in monocytes, macrophages, neutrophils, dendritic cells and epithelial cells and tumor cells, etc., can play a natural immune role in bacterial, viral, fungal and other pathogen infections, and through its intracellular Signal transduction leads to adaptive immunity. TLR2 expression and immune response are also regulated by pathogens, hormones and cytokines.