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肝细胞移植(hepatocyte transplantation,HTx)是将正常肝组织分离纯化以获得游离的有活性的肝细胞,通过不同途径定植于适当的靶器官,使之增殖并发挥作用以代替受损的肝脏。肝细胞移植被认为是可以代替肝移植治疗遗传性代谢性肝病和急慢性肝衰竭的有效方法,也可为肝移植手术作术前术后的肝功能支持,在缺乏肝源供体的情况下也可作暂时支持作用[1],延长患者等待肝移植的时间。
Hepatocyte transplantation (hepatocyte transplantation, HTx) is the isolation and purification of normal liver tissue to obtain free and active liver cells, colonized by appropriate ways to appropriate target organs, to proliferate and play a role in place of the damaged liver. Hepatocyte transplantation is considered as an effective alternative to liver transplantation in the treatment of hereditary metabolic liver disease and acute and chronic liver failure. Hepatocyte transplantation can also be used for liver function support before and after liver transplantation. In the absence of liver-derived donor Can also be used as a temporary support [1], to extend the waiting time for liver transplantation.