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目的观察周剂量紫杉醇(PTX)联合吡喃阿霉素(THP)治疗晚期乳腺癌的疗效及安全性。方法对入组的53例经病理证实的晚期乳腺癌患者应用周剂量PTX+THP联合化疗,每21天为1周期,至少2周期后评价疗效。结果53例均可评价疗效,总有效率为56.6%;其中完全缓解率为17%,部分缓解率为39.6%。不良反应主要为骨髓抑制、脱发、恶心、呕吐等。其中白细胞减少和胃肠道反应多为Ⅰ~Ⅱ度;脱发发生率为71.7%,其中Ⅲ度脱发发生率39.6%。结论周剂量紫杉醇联合吡喃阿霉素是治疗晚期乳腺癌疗效高、安全性好的化疗方案,尤其适合于一般状况较差及老年患者,值得临床推广。
Objective To observe the efficacy and safety of weekly paclitaxel (PTX) combined with pirarubicin (THP) in the treatment of advanced breast cancer. Methods A total of 53 patients with pathologically confirmed advanced breast cancer were treated with weekly PTX + THP combined with chemotherapy every 21 days for at least 2 cycles. Results All the 53 cases could evaluate the curative effect, the total effective rate was 56.6%. The complete remission rate was 17% and the partial remission rate was 39.6%. Adverse reactions mainly bone marrow suppression, hair loss, nausea, vomiting and so on. Including leukopenia and gastrointestinal reactions were mostly Ⅰ ~ Ⅱ degree; the incidence of hair loss was 71.7%, of which Ⅲ degree hair loss rate of 39.6%. Conclusion Weekly dosage of paclitaxel combined with pirarubicin is a highly effective and safe chemotherapy regimen for advanced breast cancer. It is especially suitable for patients with poor general condition and elderly patients and is worthy of clinical promotion.