作者用高效液相色谱法（ＨＰＬＣ）对苦参碱的大鼠药物动力学进行研究。其药时曲线符合２室开放模型，Ｋａ为３．４００／ｈ，Ｋｅ为０．５２３／ｈ，Ｔ１／２为３．９７１ｈ。组织分布以肾脏最高，依次为脾、肺、脑、心、血；脏器药物浓度约在０．５ｈ达峰值（肺在１ｈ达峰值），与血药浓度一致，给药后４８ｈ仍可测得。药物主要经肾脏排泄。苦参碱的吸收完全而迅速，长期给药不存在积蓄。 The authors studied the pharmacokinetics of matrine in rats using high performance liquid chromatography (HPLC). The drug time curve was in line with the 2-chamber open model, Ka was 3.400/h, Ke was 0.523/h, and T1/2 was 3.971 h. The tissue distribution was highest in the kidneys, followed by spleen, lung, brain, heart, and blood; the organ concentration reached peak value at about 0.5 h (lung peaked at 1 h), which was consistent with blood drug concentration, and could be measured at 48 h after administration. Got it. Drugs are mainly excreted by the kidneys. Absorption of matrine is complete and rapid, and there is no accumulation of long-term administration.