角化棘皮瘤最近被列为良性肿瘤。既往,它的分类变化繁杂。角化棘皮瘤与鳞状细胞癌的发生率之比,通常报告为1∶3左右,也有报告为1∶2及2∶1。病因还不清楚。考虑与化学致癌物质、创伤、日光照射等有关。也曾假定是病毒引起,但是,近年来电子显微镜下没有发现病毒样物体。 Keratoacanthoma has recently been classified as a benign tumor. In the past, its classification has changed dramatically. The ratio of the incidence of keratoacanthoma to squamous cell carcinoma is usually reported at around 1:3, and also reported at 1:2 and 2:1. The cause is not yet clear. Consider chemical carcinogens, trauma, sun exposure, etc. It was also assumed to be caused by a virus, but no virus-like objects have been found under electron microscopy in recent years.