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目的总结我国多发性骨髓瘤(MM)患者的细胞遗传学特点及其临床意义。方法回顾性分析我院100例 MM 患者的细胞遗传学结果。结果 (1)患者总体的克隆性染色体畸变(CA)检出率为17.2%;纳入亚克隆后 CA 检出率为37.0%;其中亚二倍体最多见;13号染色体异常(C13A)检出率为6.0%,其荧光原位杂交(FISH)检出率为33.3%;14号染色体易位和/或14q32异常检出率6.0%;(2)单因素分析示克隆性 CA、非超二倍体和 C13A 都使患者的总体生存时间(OS)和疾病进展时间(TTP)显著缩短;多因素分析中仅 C13A 具有独立预后意义。结论 C13A、非超二倍体、超二倍体、免疫球蛋白重链(IgH)易位等 CA 在我国 MM 患者中具有重现性。预后分析显示 C13A是独立预后不良因素。
Objective To summarize the cytogenetic features and clinical significance of multiple myeloma (MM) in our country. Methods The cytogenetic results of 100 MM patients in our hospital were retrospectively analyzed. Results (1) The overall detection rate of clonal chromosome aberration (CA) in patients was 17.2%. The detection rate of CA was 37.0% after inclusion in subclones. The sub-diploid was the most common and the detection of chromosome 13 abnormality (C13A) (6.0%). The detection rate of FISH was 33.3%. The detection rate of chromosome 14 translocation and / or 14q32 was 6.0%. (2) Univariate analysis showed that the clonal CA, Both ploidy and C13A significantly shortened the patients’ overall survival time (OS) and disease progression time (TTP). Only C13A had independent prognostic significance in multivariate analysis. Conclusion The C13A, non-diploid, diploid, immunoglobulin heavy chain (IgH) translocation and other CA patients with MM in our country with reproducibility. Prognostic analysis showed that C13A was an independent prognostic factor.