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采用双抗体夹心ＥＬＩＳＡ方法，对正常人、声带息肉病人及喉鳞状细胞癌病人的血清可溶性白细胞介素２受体（ｓＩＬ—２Ｒ）和肿瘤坏死因子（ＴＮＦ）水平进行检测。结果表明，喉癌患者血清ＳＩＬ－２Ｒ水平和ＴＮＦ活性均明显高于正常人及声带息肉病人，差异非常显著（Ｐ＜０．０１，Ｐ＜０．００１）。且血清ｓＩＬ－２Ｒ水平与喉癌的病理分化程度、临床分型、分期及手术前后具有明显的相关趋势，ＴＮＦ则不明显。提示：动态观察血清ｓＩＬ－２Ｒ及ＴＮＦ的变化，可作为分析体内抗肿瘤效应、评价疗效及监测预后的参考指标。
Serum soluble interleukin 2 receptor (sIL-2R) and tumor necrosis factor (TNF) levels were measured in patients with normal, vocal cord polyps and laryngeal squamous cell carcinoma using double antibody sandwich ELISA. The results showed that serum SIL-2R level and TNF activity in patients with laryngeal cancer were significantly higher than those in normal people and vocal cord polyp patients (P <0.01, P <0.001). Serum sIL-2R levels and pathological differentiation of laryngeal cancer, clinical type, stage and before and after surgery had a significant trend, TNF was not obvious. It is suggested that dynamic observation of the changes of serum sIL-2R and TNF can be used as a reference index for the analysis of anti-tumor effect in vivo and evaluation of curative effect and prognosis.