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目的:研究索布佐生(Sob)与阿霉素(Dox)联合应用的抑瘤作用以及Sob对Dox诱导的心脏毒性的影响。方法:DBA/2小鼠接种P388细胞,次日起iv Dox 2mg·kg~(-1)·d~(-1)×3d及4mg·kg~(-1)·d~(-1)×1 d,ig Sob 20mg·kg~(-1)·d~(-1)×7d及40mg·kg~(-1)·d~(-1)×7d,配对联用。统计各组的生命延长率(ILS);电镜观察荷瘤鼠垂死前的心肌毒性表现。结果:联合用药组的ILS分别为48.7％,57.3％,59.0％和62.4％,是Sob和Dox单药应用ILS之和的130％—190％,荷瘤鼠心肌细胞的超微结构损伤较单用Dox组明显减轻。结论:Sob与Dox联用对小鼠白血病P388有显著的抑瘤协同作用;Sob能降低Dox所致的心肌毒性。
Objective: To study the anti-tumor effect of Sob and Dox combined with Sox on Dox-induced cardiotoxicity. METHODS: P388 cells were inoculated into DBA/2 mice, and the following day iv Dox 2 mg·kg~(-1)·d~(-1)×3d and 4 mg·kg~(-1)·d~(-1)× 1 d, ig Sob 20mg · kg -1 · d -1 × 7d and 40mg · kg -1 · d -1 × 7d, paired with. The prolongation of life (ILS) of each group was counted; electron microscopy was performed to observe the myocardial toxicity of the tumor-bearing mice before dying. RESULTS: The ILS of the combination group was 48.7%, 57.3%, 59.0%, and 62.4%, respectively, which was 130% to 190% of the sum of the ILS administered by Sob and Dox alone. The ultrastructural damage of myocardial cells in the tumor-bearing mice was higher than that of the control group. With the Dox group significantly reduced. Conclusion: The combination of Sob and Dox has significant anti-tumor synergistic effect on mouse leukemia P388; Sob can reduce Dox-induced myocardial toxicity.