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目的探讨脂蛋白(a)(Lp(a))与老年糖尿病性肾病肾功能不全的关系。方法分析47例老年对照组和141例不同肾小球滤过率的老年糖尿病肾病患者的脂蛋白(a)、血脂及载脂蛋白浓度的变化。结果老年糖尿病性肾病肾功能正常组Lp(a)己有升高趋势(P=0.072),随着肾功能的减退Lp(a)显著增高(P<0.001),并且与肾小球滤过率呈负相关,同时冠心病和脑血管病发生率也明显上升。结论Lp(a)升高在老年糖尿病性肾病肾功能不全的发展过程中起重要作用。
Objective To investigate the relationship between lipoprotein (a) (Lp (a)) and renal insufficiency in elderly patients with diabetic nephropathy. Methods The levels of lipoprotein (a), lipids and apolipoproteins in 47 elderly controls and 141 elderly diabetic nephropathy patients with different glomerular filtration rate (GFR) were analyzed. Results Lp (a) had a tendency to increase in elderly patients with diabetic nephropathy (P = 0.072), Lp (a) was significantly increased with the decline of renal function (P <0.001), and was associated with glomerular filtration rate Was negatively correlated, while the incidence of coronary heart disease and cerebrovascular disease also increased significantly. Conclusion Lp (a) elevation plays an important role in the development of renal insufficiency in elderly diabetic nephropathy.