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本文意图是鉴定对慢性哮喘病儿连续地日夜给予单用或联用口服通用剂量或大剂量茶碱及麻黄素的效果和安全性。作为研究病例的12名儿童,年龄为6～12岁,均符合哮喘诊断标准,且都无长期皮质激素和注射变态反应性提取物的治疗史,亦无危及生命的哮喘反复发作史。研究的治疗方法分组如下:(1)大剂量麻黄素,1.3～2.1毫克/公斤/次;(2)大剂量氨茶碱,6.3～10.7毫克/公斤/次;(3)合用(1)+(2)的大剂量麻黄素和氨茶碱;(4)用(3)的两药1/2剂量(近于通用剂量)。于总治疗方案的4周期间,每一病儿都是每6小时投药1次。治疗期间若有急性哮喘症状发作,则按病情加用其他止喘疗法。如果症状仍持续,则暂停研究用药,至少须在6小时的无症状期后,才能恢复用药。开始治疗后每日3次测定肺功
This article intends to identify the efficacy and safety of continuous, single-or combination oral or usual doses of theophylline and ephedrine administered to children with chronic asthma. As a study case, 12 children, aged 6-12 years, all met the diagnostic criteria for asthma and had no history of long-term corticosteroids and injection of allergic extracts and no history of life-threatening recurrent asthma attacks. The treatments studied are grouped as follows: (1) High-dose ephedrine, 1.3-2.1 mg / kg / second; (2) High dose aminophylline, 6.3-10.7 mg / (2) of the high-dose ephedrine and aminophylline; (4) with two doses of (3) 1/2 dose (nearly universal dose). During the four weeks of the total treatment regimen, each sick child dosed once every 6 hours. If the onset of acute asthma symptoms during treatment, according to the disease plus other anti-asthma therapy. If the symptoms persist, stop dosing study, at least 6 hours after the asymptomatic period in order to resume medication. Pulmonary function was measured 3 times a day after starting treatment