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目的探讨老年T2DM患者血清维生素D[25(OH)D_3]水平与同型半胱氨酸(Hcy)及IS的相关性。方法选取T2DM患者122例,按25(OH)D_3值分为正常(ND_3)组[25(OH)D_3≥30ng/ml]、不足(InsD_3)组[20≤25(OH)D_3<30 ng/ml]、缺乏(DefD_3)组[10≤25(OH)D_3<20 ng/ml]和严重缺乏(SdefD_3)组[25(OH)D_3<10 ng/ml],观察4组间Hcy,FPG、FIns,胰岛素敏感指数(ISI)和HbA_1c的差异。结果 4组Hcy、FPG、FIns、ISI、Hb A_1c、25(OH)D_3比较,差异有统计学意义(P<0.01),并随着25(OH)D_3的降低,Hcy,FPG,FIns、HBA_1c均随之升高,而ISI逐渐降低(P<0.05)。结论 FPG、FIns、ISI、HbA_(1C)、Hcy与老年T2DM患者25(OH)D_3水平密切相关。25(OH)D_3可降低FPG,增加IS,改善胰岛功能,对预防和更好地控制糖尿病并发症有一定的临床意义。
Objective To investigate the relationship between serum vitamin D [25 (OH) D_3] and homocysteine (Hcy) and IS in elderly patients with T2DM. Methods Twenty-two T2DM patients were divided into two groups according to their 25 (OH) D_3 values: 25≤OH (OH) D_3≥30ng / ml, InsD_3≤20ng / ml, 25 mg / ml D_3, 10 ng / ml and 10% 25 (OH) D_3 in the DefD_3 group and 25% in the SdefD_3 group. FIns, insulin sensitivity index (ISI) and HbA_1c differences. Results There were significant differences in Hcy, FPG, FIns, ISI, Hb A 1c and 25 (OH) D 3 between the four groups (P <0.01) Both increased, while ISI decreased gradually (P <0.05). Conclusion FPG, FIns, ISI, HbA_ (1C) and Hcy are closely related to 25 (OH) D_3 in elderly patients with T2DM. 25 (OH) D_3 can reduce FPG, increase IS, improve pancreatic islet function, and have certain clinical significance in preventing and better controlling diabetic complications.