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为探讨硬化药物对人体囊肿的治疗作用机制，评价不同硬化药物的疗效，建立家兔胆囊动物实验模型。７５只家兔分成３组，手术结扎胆囊管，生理盐水冲洗后注入两组硬化药物，１ｄ、３ｄ、７ｄ、１４ｄ、２１ｄ手术切除胆囊取材。结果：组合硬化剂实验组胆囊壁上皮细胞破坏均匀，囊内渗液、出血量少，吸收快，纤维化明显；无水乙醇对照组胆囊壁反应剧烈，上皮细胞破坏不均衡，囊内渗液、出血多，吸收慢，纤维组织增生少；生理盐水空白组胆囊上皮细胞无改变。
In order to investigate the therapeutic mechanism of sclerotherapy drugs on human cysts and evaluate the efficacy of different sclerosing agents, an experimental animal model of gallbladder in rabbits was established. Seventy-five rabbits were divided into three groups. The cystic ducts were surgically ligated, and the sclerosing agents were injected into saline after washing. The gallbladder was resected after 1d, 3d, 7d, 14d, and 21d. RESULTS: The gallbladder wall epithelial cells in the combined sclerosing agent experimental group had a uniform destruction, with less effusion, less bleeding, rapid absorption and fibrosis. The absolute ethanol control group had severe gallbladder wall reaction, and the epithelial cells were damaged unbalancedly. Bleeding was more, absorption was slower, and fibroplasia was less; normal saline blank group had no change in gallbladder epithelial cells.