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目的探讨精液异常与染色体异常及多态的关系。方法选取临床诊断为无精症和少、弱精症的764例男性患者行常规外周血染色体G显带核型分析,同时选取862例正常生育男性作为对照组。结果 764例精液异常患者中,染色体异常发生率为17.06%(130/764),常染色体异常率为2.09%(16/764);性染色体异常率为14.92%(114/764);染色体多态占5.37%(41/764)。精液正常对照组中,常染色体异常率为0.81%(7/862);性染色体异常率为0.58%(5/862);染色体多态性占4.99%(43/862)。精液异常组与精液正常组比较:常染色体异常,有显著性差异(P<0.05);性染色体异常,有显著性差异(P<0.05);多态性,无显著性差异(P>0.05)。结论我们研究提示,性染色数目的异常和Y染色体结构的异常是导致无精症和少、弱精症的一个重要因素,对男性不育患者行染色体检查十分有必要;但染色体多态与生精障碍无明显相关性。
Objective To explore the relationship between abnormalities of sperm and chromosomal abnormalities and polymorphisms. Methods A total of 764 male patients with azoospermia, oligospermia and asthenospermia who underwent routine G-banding karyotype analysis were enrolled, and 862 normal fertile men were selected as the control group. Results Among the 764 patients with abnormal semen, the incidence of chromosomal abnormalities was 17.06% (130/764), the rate of autosomal abnormalities was 2.09% (16/764) and the rate of sex chromosome abnormalities was 14.92% (114/764). The polymorphism Accounting for 5.37% (41/764). In the semen normal control group, the rate of autosomal abnormality was 0.81% (7/862), the rate of sex chromosome abnormality was 0.58% (5/862), and the chromosome polymorphism accounted for 4.99% (43/862). There was a significant difference (P <0.05) between the abnormal semen group and the normal semen group: autosomal abnormality had significant difference (P <0.05); sex chromosome abnormality had no significant difference (P> 0.05) . Conclusions Our study suggests that the abnormality of the number of sex chromosomes and the abnormality of the Y chromosome structure are an important factor leading to azoospermia and oligozoospermia. It is necessary to perform chromosome examination in male infertility patients. However, No significant correlation between the impairment of fineness.