论文部分内容阅读
目的:研究肝癌患者血浆IL-1活性及TNF-α含量,为进一步探索肝癌发病机理提供资料。方法:应用同位素掺入法、酶联法检测了肝癌患者血浆白细胞介素-1(IL-1)活性和肿瘤坏死因子α(TNF-α)含量。结果:肝癌患者血浆IL-1活性明显低于对照组,而血浆TNF-α含量却显著高于对照组。结论:肝癌患者巨噬细胞活性受抑制,TNF可能部分来自肝癌细胞的自身分泌。
Objective: To study the plasma level of IL-1 and the content of TNF-α in patients with hepatocellular carcinoma (HCC), and to provide information for further exploring the pathogenesis of HCC. Methods: The levels of plasma interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) in patients with hepatocellular carcinoma were detected by isotope incorporation and enzyme-linked immunosorbent assay. Results: The activity of plasma IL-1 in patients with hepatocellular carcinoma was significantly lower than that of the control group, but the plasma TNF-α content was significantly higher than that of the control group. Conclusion: The activity of macrophages in HCC patients is inhibited, and TNF may be partly from the self-secretion of HCC cells.