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利用低毒廉价的乙腈溶剂作为新型“CN”源,开发了铜催化下芳基碘化物氰化反应.其中六甲基二硅烷可以促进铜盐对乙腈C—CN键的断裂,而2,2,6,6-四甲基哌啶-氮-氧化物(TEMPO)作为温和的氧化剂,对产率的提高至关重要.在Cu/TEMPO/Si体系下显示出了底物良好的兼容性和反应性.无论是富电子或缺电子取代基的底物都能够兼容.最后根据反应结果和文献推测了反应机理.
Copper-catalyzed cyanidation of aryl iodides was developed using a low-toxic, low-cost, acetonitrile-based solvent as a new “CN” source, with hexamethyldisilane promoting the cleavage of the C-CN bond by acetonitrile and 2 , 2,6,6-tetramethylpiperidine-nitrogen-oxide (TEMPO), as a mild oxidant, is of crucial importance for improving the yield and shows a good compatibility of the substrate under the Cu / TEMPO / Si system Sex and reactivity.Whether it is electron-rich or electron-deficient substrate, it can be compatible.Finally, the reaction mechanism is deduced from the reaction results and literature.