八乙基卟啉以吡咯为合成前体 ,主要有 2种基本合成路线 ,一是以 5-甲基 -3 ,4 -二乙基 -2 -乙氧羰基吡咯为合成前体 ,由吡咯 α位甲基的碳原子构成卟啉的次甲基桥 ,另一路线是以 3 ,4 -二乙基吡咯为合成前体经与甲醛缩合 ,并以甲醛碳原子构成卟啉的次甲基桥 ,本文详细地介绍了这些中间体和八乙基卟啉的合成 ,并对比较典型的 6种全合成方法进行了评述 There are two basic routes to the synthesis of p - ethylporphyrin with pyrrole as precursor. One is the synthesis of 5 - methyl - 3, 4 - diethyl - 2 - Methyl carbon atoms constitute the methine bridge of porphyrin, the other route is 3,4 - diethyl pyrrole as a precursor of synthesis by condensation with formaldehyde and formalin carbon atoms constitute a porphyrin of the methine bridge , This paper describes in detail the synthesis of these intermediates and octaethylporphyrin, and compares the typical six kinds of total synthesis methods were reviewed