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目的:探讨减少GnRHa剂量对长方案促排卵的卵巢反应性影响。方法:对37例采用长方案进行促排卵且第一周期未妊娠或流产的患者进行自身对照研究,第一个周期GnRHa用量为0.05mg/d,第二个周期GnRHa用量为0.03mg/d。结果:Gn使用天数、Gn用量、受精率第一、第二促排卵周期间无显著性差异(P>0.05)。获卵数、可移植胚胎数第二周期组较第一周期组显著增加(P<0.05)。结论:本研究认为在长方案促排卵过程中减少GnRHa的剂量可以增加获卵数,改善卵巢反应性,增加IVF妊娠率。
Objective: To investigate the effects of GnRHa dose reduction on ovarian response to ovulation induction by long protocol. Methods: 37 patients with long-term ovulation induction and the first cycle of non-pregnancy or abortion patients self-control study, the first cycle GnRHa dosage of 0.05mg / d, the second cycle GnRHa dosage of 0.03mg / d. Results: There was no significant difference in the number of Gn days, Gn dosage, fertilization rate and the second ovulation induction period (P> 0.05). The number of oocytes retrieved, the number of transferable embryos in the second cycle group increased significantly compared with the first cycle group (P <0.05). Conclusion: This study suggests that reducing the dose of GnRHa during long-term ovulation induction may increase the number of oocytes retrieved, improve ovarian response and increase the pregnancy rate of IVF.