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目的探讨血清糖类抗原125(CA125)和糖类抗原199(CA199)在卵巢肿瘤诊断中的意义。方法采用化学发光法检测2010年1月至2011年12月收治的196例卵巢肿瘤患者(良性肿瘤组140例、交界性肿瘤组13例、恶性肿瘤组43例)和50例健康体检者(对照组)的血清CA125和CA199。比较两种肿瘤标记物单检及联检在卵巢肿瘤诊断中的敏感度和特异度。结果 (1)CA125在卵巢良性肿瘤、交界性肿瘤和恶性肿瘤的表达水平分别为(19.80±13.57)U/ml、(94.59±53.41)U/ml和(759.00±677.26)U/ml,均高于对照组水平(9.94±5.64)U/ml,各组之间差异有统计学意义(P<0.05);(2)CA199在卵巢良性肿瘤、交界性肿瘤和恶性肿瘤的表达水平分别为(69.13±72.08)U/ml、(167.70±19.22)U/ml和(184.00±93.26)U/ml,均高于对照组水平(13.42±11.16)U/ml,但各组之间差异无显著意义(P>0.05);(3)CA125在卵巢恶性肿瘤诊断中敏感度、特异度为76.7%和90.0%,均高于CA199,两者联合检测并没有明显提高敏感度,反而降低了特异度。结论 CA125可作为卵巢肿瘤诊断的生物指标,而CA199的敏感度和特异度均较低,临床意义不大,两者联合检测并没有比CA125单项检测更具优势。
Objective To investigate the significance of serum carbohydrate antigen 125 (CA125) and carbohydrate antigen 199 (CA199) in the diagnosis of ovarian tumors. Methods Chemiluminescence was used to detect 196 cases of ovarian tumors (140 cases of benign tumor, 13 cases of borderline tumor, 43 cases of malignant tumor) and 50 cases of healthy subjects (control group) from January 2010 to December 2011 Group) of serum CA125 and CA199. To compare the sensitivity and specificity of single and combined detection of two tumor markers in the diagnosis of ovarian tumors. Results (1) The expression levels of CA125 in benign ovarian tumors, borderline tumors and malignant tumors were (19.80 ± 13.57) U / ml, (94.59 ± 53.41) U / ml and (759.00 ± 677.26) U / (9.94 ± 5.64) U / ml in the control group (P <0.05). (2) The expression levels of CA199 in benign ovarian tumors, borderline tumors and malignant tumors were (69.13 (167.70 ± 19.22) U / ml and (184.00 ± 93.26) U / ml were higher than that of the control group (13.42 ± 11.16 U / ml), but there was no significant difference between the groups P> 0.05). (3) The sensitivity and specificity of CA125 in the diagnosis of ovarian cancer were 76.7% and 90.0%, both higher than CA199. The combined detection of CA125 and CA125 did not significantly improve the sensitivity, but decreased the specificity. Conclusions CA125 can be used as a biomarker for the diagnosis of ovarian tumors. However, the sensitivity and specificity of CA199 are low and have little clinical significance. The combined detection of CA125 and CA125 has no advantage over the single detection of CA125.