赖氨酸羟化酶(lysyl hydroxylase,LH)是催化胶原蛋白和另外15种以上蛋白质中赖氨酸羟化的酶类,它在一些生理和病理过程中扮演着重要的角色。LH有多种同工酶,其活性需依赖一些辅基的存在,同时也受到一些物质的抑制。研究发现一些组织纤维化性疾病和遗传性疾病与LH有很大的关系。近年来,随着对该酶研究的深入,有望找到这些疾病治疗的新靶点。 Lysyl hydroxylase (LH), an enzyme that catalyzes the hydroxylation of lysine among collagen and more than 15 other proteins, plays an important role in some physiological and pathological processes. LH has a variety of isozymes, its activity depends on the presence of some prosthetic groups, but also by some substance inhibition. The study found that some of the tissue fibrosis and genetic diseases and LH have a great relationship. In recent years, with the deepening of the enzyme research, is expected to find a new target for the treatment of these diseases.