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目的:探讨恩丹西酮对肿瘤化疗患者食管内pH值的影响。方法:40名患者随机分为2组,观察组恩丹西酮静脉给药,对照组化疗时未用止吐药。化疗同时进行食管内24hpH监测。结果:食管内pH<4总时间百分(比)、最长酸反流时间(min)、酸反流>5min次数、酸反流次数均低于对照组。结论:恩丹西酮能有效地预防化疗所致的胃食管反流。
Objective: To investigate the effect of ondansetron on esophageal pH value in patients with chemotherapy. Methods: Forty patients were randomly divided into two groups. Ondansetron was given intravenously in the observation group and no antiemetic drug in the control group. Chemotherapy at the same time 24hpH esophageal monitoring. Results: The esophageal pH <4 the percentage of total time, the longest acid reflux time (min), acid reflux> 5 minutes, the number of acid reflux were lower than the control group. Conclusion: Ondansetron can effectively prevent gastroesophageal reflux caused by chemotherapy.