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目的探讨人外周血白细胞介素21(interleukin-21,IL-21)与卵巢早衰(premature ovarian failure,POF)及卵巢功能减退(decreased ovarian reserve,DOR)的发病是否相关。方法收集POF患者25例、DOR患者14例以及健康体检的育龄女性18例作为对照,采用放射免疫法检测血清IL-21水平,并与其他实验室指标进行相关性分析。结果 POF组和DOR组患者的血清IL-21水平较对照组明显升高,差异有统计学意义(F=4.971,P=0.010),POF组和DOR组患者的血清IL-21水平近似,差异无统计学意义(P>0.05)。IL-21分别与促卵泡激素(follicle stimulating hormone,FSH)、抗苗勒管激素(anti-miillerian hormone,AMH)呈正相关(r=0.389,P=0.003;r=0.275,P=0.040),IL-21分别与雌二醇(estradiol,E2)、平均卵巢体积(mena ovarian volume,MOV)呈负相关(r=-0.377,P=0.004;r=-0.271,P=0.042)。结论血清IL-21在POF患者中升高,而且在DOR患者中明显升高,并与卵巢储备功能相关,提示IL-21可能参与早期POF的发病过程,可望成为防治POF的新途径。
Objective To investigate whether human peripheral blood interleukin-21 (IL-21) is associated with the pathogenesis of premature ovarian failure (POF) and ovarian reserve (DOR). Methods Twenty-five POF patients, 14 DOR patients and 18 healthy women of childbearing age were collected as control. Serum IL-21 levels were measured by radioimmunoassay and correlation with other laboratory parameters. Results The levels of serum IL-21 in POF group and DOR group were significantly higher than those in control group (F = 4.971, P = 0.010). The levels of serum IL-21 in POF group and DOR group were similar No statistical significance (P> 0.05). IL-21 was positively correlated with follicle stimulating hormone (FSH) and anti-miillerian hormone (AMH) (r = 0.389, P = 0.003; -21 were negatively correlated with estradiol (E2) and mena ovarian volume (r = -0.377, P = 0.004; r = -0.271, P = 0.042). Conclusions Serum IL-21 is elevated in patients with POF, and is significantly elevated in DOR patients and is correlated with ovarian reserve. It suggests that IL-21 may be involved in the pathogenesis of early POF and is expected to be a new way to prevent and treat POF.