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目的：为诱导受体对异种供体的免疫耐受．方法：作者把大鼠的胸腺和骨髓联合移植给经去胸腺、去脾等预处理的受体新西兰兔． 结果：在不用任何免疫抑制剂的情况下，大鼠细胞能以很高比例（６１９％ ～２８８％ ）在受体兔体内存活２４５ ｄ 以上，未观察到受体兔有移植物抗宿主病的症状；并发现这些大鼠细胞能与较高水平的兔抗大鼠抗体同时存在于实验兔体内，且证明这些抗体未结合到实验兔体内的大鼠细胞上． 结论：这些抗体对应的抗原在这些大鼠细胞表面是“缺失”的，并证明这些“缺失”的分子中不包括 Ｍ Ｈ ＣⅠ类分子． 从实验兔体内检测出大鼠抗乙脑病毒抗体的实验结果看，这些分子的“缺失”并不影响大鼠免疫细胞的体液免疫功能．
OBJECTIVE: To induce the immune tolerance of the recipient to xeno-donor. METHODS: The authors co-transplanted the thymus and bone marrow of rats to New Zealand rabbits pretreated with de thymus and spleen. Results: In the absence of any immunosuppressive agents, rat cells survived more than 245 days in a very high proportion (619% -288%) in recipient rabbits, and no graft was observed in recipient rabbits Anti-host disease symptoms; and found that these rat cells with higher levels of rabbit anti-rat antibody co-exist in experimental rabbits, and proved that these antibodies do not bind to experimental rat body in rat cells. Conclusion: The antigens corresponding to these antibodies are “missing” on the surface of these rat cells and demonstrate that these “missing” molecules do not include M H C class I molecules. The experimental results of detecting anti-JEV antibodies in experimental rabbits showed that the “absence” of these molecules did not affect the humoral immune function of rat immune cells.