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我院1998年以来在肺结核化疗期间,共发生类赫反应14例,现报道并结合文献复习如下。1 临床资料1.1 一般资料 本组均为初治患者,男11例,女3例,年龄20~68岁,Ⅱ型2例(14.3%),Ⅲ型11例(78.4%),Ⅴ型1例(7.1%),痰菌阳性12例(85.8%),阴性2例(14.2%),化疗方案:HR1例,HRS4例,HRSZ6例,HRSE3例。类赫反应表现为:除高热1例,胸痛、胸闷2例外,其余症状均较轻,反应发生时间:在化疗1个月内4例,2个月内8例,3个月内2例,胸片情况:病灶暂时性增多、增大8例;胸膜炎3例,肺门和(或)纵隔淋巴结增大3例;痰菌:12例阴性,2例阳性。
In our hospital since 1998 during tuberculosis chemotherapy, a total of 14 cases of Hehe reaction occurred, are reported and combined with the literature review below. 1 Clinical data 1.1 General Information The group of patients with untreated patients, 11 males and 3 females, aged 20 to 68 years old, Ⅱ type in 2 cases (14.3%), Ⅲ type in 11 cases (78.4%), Ⅴ in 1 case (7.1%), sputum positive in 12 (85.8%) and negative in 2 (14.2%). The chemotherapy regimen included 1 HR, 4 HRS, 6 HRS and 3 HRSE. Class Hehe reaction showed: in addition to high fever in 1 case, chest pain, chest tightness in 2 cases, the rest of the symptoms were mild, the reaction time: 4 months within 1 month of chemotherapy, 2 cases within 2 months, 2 cases within 3 months, Thoracic conditions: lesions increased temporarily, increased in 8 cases; pleurisy in 3 cases, hilar and (or) mediastinal lymph nodes increased in 3 cases; sputum: 12 cases were negative and 2 cases were positive.