论文部分内容阅读
利用三种手性固定相对６种Ｎ－乙酰化ＤＬ－氨基酸酯进行了手性分离研究，结果表明：Ｎ－乙酰化ＤＬ－氨基酸酯的手性分离系数α随氨基酸手性中心基团Ｒ１和衍生化基团Ｒ２的增大而增大，同时ＣＳＰ具有手性识别的手性中心基团空间位阻的增大也有利于改善手性分离效果，对映体的馏出顺序取决于ＣＳＰ具有手性识别的手性中心的构型，本文还为已提出的Ｎ－乙酰化ＤＬ－氨基酸酯在该类手性固定相上的手性分离机理进行了补充．
The chiral separation of six N-acetylated DL-amino acid esters with three chiral stationary phases was studied. The results showed that the chiral separation coefficient α of N-acetylated DL-amino acid esters varies with the chiral center groups R1 and The increase of the derivatization group R2 and the increase of the steric hindrance of the chiral center group with CSP also help to improve the chiral separation effect. The order of enantiomer distilling depends on the CSP has The chiral center configuration of chiral recognition is also complemented by the proposed chiral separation mechanism of N-acetylated DL-amino acid esters on such chiral stationary phases.