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本文对儿科医院1956年9月至1983年8月住院的过敏性紫癜肾炎(APN)180例作了临床分析,其临床表现为血尿和/或蛋白尿者占51.1%、肾炎综合征者占43.3%、肾病综合征伴血尿者占5.6%。肾损害与肾外症状无明显关系,用激素治疗与否对近期结局无明显影响,近期临床痊愈40.6%、好转42.2%、无变化16.1%、死亡1.1%。 76例随访11月至26年(平均9年),体检无异常发现。在资料完整的50例中痊愈30%、尿异常24%、尿异常伴轻度氮质血症46%。作肾活检7例,其血清C_3均正常,经光镜、电镜、免疫荧光检查2例呈膜增殖肾炎、5例呈系膜增殖肾炎,未见新月体形成,有IgA沉积者5/6例。本组APN的预后较其它文献报告佳。
In this paper, 180 cases of allergic purpura nephritis (APN) hospitalized in pediatric hospital from September 1956 to August 1983 were analyzed. The clinical manifestations were hematuria and / or proteinuria in 51.1% and nephritic syndrome in 43.3 %, Nephrotic syndrome with hematuria accounted for 5.6%. No significant relationship between renal damage and extra-renal symptoms, hormone therapy or no immediate effect on the outcome, the recent clinical cure 40.6%, improved 42.2%, no change 16.1%, 1.1% of deaths. 76 cases were followed up from November to 26 years (average 9 years), no abnormal physical examination. In the data complete 50 cases healed 30%, 24% urinary abnormalities, urinary abnormalities with mild azotemia 46%. 7 cases of renal biopsy, the serum C_3 were normal, by light microscopy, electron microscopy, immunofluorescence showed two cases of proliferative nephritis, mesangial proliferative nephritis in 5 cases, no crescent formation, IgA deposition 5/6 example. The prognosis of this group of APN reported better than other literature.