论文部分内容阅读
目的:探讨骨桥蛋白(0PN)与CD44v6在人胰腺癌中的表达,并分析OPN、CD44v6与胰腺癌临床病理特性的关系。方法:应用免疫组织化学方法检测OPN、CD44v6在43例胰腺癌、34例癌旁组织中的表达。结果:43例胰腺癌标本中OPN、CD44v6阳性表达率分别为65.1%、62.7%,34例胰腺癌旁组织OPN、CD44v6阳性表达率均为20.6%;有淋巴结转移的胰腺癌组织中OPN、CD44v6表达阳性率分别为86.7%、80.0%,无淋巴结转移者为53.5%、53.6%,二者相比差异均有显著性(P<0.05);组织学分级为Ⅲ级的胰腺癌组织中CD44v6的表达率为85.7%,组织学分级为Ⅰ～Ⅱ级的胰腺癌组织中CD44v6的表达率为51.7%,二者相比差异有显著性(P<0.05);CD44v6与OPN的表达呈正相关,相关系数r为0.446(P<0.05)。结论:OPN、CD44v6在胰腺癌的浸润、转移中可能起重要作用,它们可作为胰腺癌浸润、转移及评估预后的指标。
Objective: To investigate the expression of osteopontin (0PN) and CD44v6 in human pancreatic cancer and to analyze the relationship between OPN, CD44v6 and clinicopathological features of pancreatic cancer. Methods: Immunohistochemistry was used to detect the expression of OPN and CD44v6 in 43 cases of pancreatic cancer and 34 cases of adjacent tissues. Results: The positive rates of OPN and CD44v6 in pancreatic cancer specimens were 65.1% and 62.7% respectively, and the positive rates of OPN and CD44v6 in 34 cases of pancreatic cancer tissues were 20.6%. The expressions of OPN and CD44v6 in pancreatic cancer tissues with lymph node metastasis The positive expression rate of CD44v6 in pancreatic cancer tissue with histological grade Ⅲ was 86.7%, 80.0%, 53.5% and 53.6% respectively (P <0.05) The positive rates of CD44v6 and OPN were 85.7% and 51.7% respectively in pancreatic carcinoma with grade Ⅰ ~ Ⅱ histological grade (P <0.05) The coefficient r was 0.446 (P <0.05). CONCLUSION: OPN and CD44v6 may play an important role in the invasion and metastasis of pancreatic cancer. They may serve as indicators of the infiltration, metastasis and prognosis of pancreatic cancer.