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青蒿素与青蒿酯钠的某些免疫作用已有报道。本文报道应用单向免疫扩散测定技术,测定了蒿甲醚对小鼠血清IgG含量的影响,还观察了蒿甲醚对脾脏重量的影响。动物用20～25g JCR纯种小鼠,按雌雄各半随机分组。蒿甲醚(桂林制药厂提供)与氯喹(重庆制药厂生产)均混悬于1％西黄蓍胶,供灌胃用。兔抗小鼠IgG抗血清及标准JCR小鼠血清抗原均为本实验室制备。
Some immunosuppressive effects of artemisinin and artesunate sodium have been reported. This article reports the application of one-way immunodiffusion assay technique to determine the effect of artemether on serum IgG levels in mice and the effect of artemether on spleen weight. Animals with 20 ~ 25g JCR purebred mice, randomly divided by male and female. Artemether (provided by Guilin Pharmaceutical Factory) and chloroquine (manufactured by Chongqing Pharmaceutical Factory) were suspended in 1% tragacanth for gavage. Rabbit anti-mouse IgG antiserum and standard JCR mouse serum antigens were prepared in our laboratory.