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目的 探索小儿睾丸恶性生殖细胞瘤合理的治疗方案。方法 Ⅰ期无高危因素 18例行睾丸高位切除术后密切随访 (A组 ) ;Ⅰ期有高危因素和Ⅱ期 31例分为 13例行睾丸切除加腹膜后淋巴结清扫加不规则化疗 (B组 ) ,10例行睾丸切除加腹膜后淋巴结清扫加规则化疗 (C组 ) ,8例行睾丸切除加规则化疗 (D组 )。结果 A组、B组间生存率差异有显著性意义 (P <0 .0 5 ) ,B组与C组、D组间生存率差异有显著性意义 (P <0 .0 5 ) ,C组、D组间生存率差异无显著性意义 (P >0 .0 5 )。结论 年龄小、分期早预后好 ,Ⅰ期有高危因素及Ⅱ期者应行与化疗的综合治疗 ,有效联合化疗可代替常规腹膜后淋巴结清扫
Objective To explore the reasonable treatment of pediatric testicle malignant germ cell tumor. Methods A total of 18 patients with high risk factors were followed up after resection of the testes (group A). The patients with stage Ⅰ risk factors and 31 cases with stage Ⅱ were divided into three groups: testis resection plus retroperitoneal lymph node dissection plus irregular chemotherapy (group B) ), 10 cases of orchidectomy combined with retroperitoneal lymph node dissection plus regular chemotherapy (C group), 8 cases of orchidectomy combined with regular chemotherapy (D group). Results There was significant difference in the survival rate between group A and group B (P <0.05), and between group B and group C and group D (P <0.05), and group C There was no significant difference in survival between D groups (P> 0.05). Conclusions Small age, good early stage of staging, stage Ⅰ risk factors and stage Ⅱ should be combined with chemotherapy, combined with chemotherapy can replace conventional retroperitoneal lymph node dissection