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1988年5月30日至6月1日,世界卫生组织(WHO)在日内瓦召开了非正式咨询会议,回顾了白喉、破伤风类毒素、百日咳菌苗及混合制剂生产及检定方法的进展,以便对研究课题和规程修改提出建议。重点是对白喉类毒素、百日咳菌苗、破伤风类毒素及混合制剂改进的安全和效力检定方法加以考虑和提出建议。白喉和破伤风类毒素会议回顾了白喉和破伤风毒素的结构,特别是关于甲醛处理的同时发生的化学和物理变化,以及纯化方法(如亲和层析)。特别重视白喉类毒素毒性回复的可能性,注意到脱
From 30 May to 1 June 1988, the World Health Organization (WHO) convened an informal consultation in Geneva to review the progress of the methods for the production and verification of diphtheria, tetanus toxoid, pertussis and mixed preparations so that Make suggestions on the research topics and procedures modification. The emphasis is on the consideration and recommendations for improved safety and efficacy testing of diphtheria toxoid, pertussis, tetanus toxoid and mixed preparations. Diphtheria and Tetanus toxoid The meeting reviewed the structures of diphtheria and tetanus toxins, in particular with regard to simultaneous chemical and physical changes in the treatment of formaldehyde, and purification methods such as affinity chromatography. Special attention to diphtheria toxoid toxicity of the possibility of recovery, noted off