“肺与大肠相表里”系祖国医学基础理论之一,对指导临床实践有重要价值。利用现代科研手段使之客观化、进而探讨其机制、无疑对深化认识,拓展临床应用范围等都是十分必要并有广阔前景的。其中,设计建立具有中医特色、病理表现及病理模型的产生过程与临床一致的动物模型;研究中、西药物对模型的影响等都是当前亟待解决的课题。为此,我们对原冯氏模型做了改进,同时采用电子显微镜、肺泡细胞灌洗术等较先进手段观察了大承气汤对模型肺脏某些功能及其病理组织学改变的影响,现报导如下。 “Pulmonary and large intestine” is one of the basic theories of the medical science in the motherland and is of great value in guiding clinical practice. The use of modern scientific research methods to make it objective, and then to explore its mechanism, undoubtedly to deepen understanding, expand the scope of clinical applications are all very necessary and have broad prospects. Among them, the design and establishment of an animal model that is consistent with the clinical process of the production process of TCM characteristics, pathological manifestations, and pathological models; and the impact of Chinese and Western drugs on the model are all issues that need to be resolved. To this end, we have improved the original Feng’s model, and at the same time used electron microscopy, alveolar cell lavage and other more advanced means to observe the effect of Dachengqi Decoction on certain lung function and histopathological changes in model lungs. as follows.