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目的观察右丙亚胺(Dexrazoxaane,DEX)对吡柔比星(Theprubicin,THP)联合化疗所致心脏毒性的防护作用。方法 60例乳腺癌患者,均采用THP为主的联合化疗方案,随机分为观察组和对照组,每组30例,观察组在第一次应用THP时即给予DEX(DEX:THP=10:1)。两组患者均按要求完成4个周期的化疗,观察其心电图、左心室射血分数(Left ventricular efection fraction,LVEF)及心肌肌钙蛋白T(Cardiac troponin T,c Tn T)的变化。结果2组心电图异常、LVEF变化从第4周期化疗后,差异均有统计学意义(P<0.05~P<0.01);2组c Tn T变化从第1周期化疗后,差异有统计学意义(P<0.01)。结论右丙亚胺对吡柔比星所致心脏毒性有一定的防护作用。
Objective To observe the protective effect of Dexrazoxaane (DEX) on the cardiotoxicity induced by chemotherapy combined with THP (Theprubicin). Methods Sixty patients with breast cancer were treated with THP combined with chemotherapy. The patients were randomly divided into observation group and control group, with 30 cases in each group. The patients in observation group were given DEX (DEX: THP = 10: 1). Both groups completed 4 cycles of chemotherapy according to the requirements and observed the changes of electrocardiogram, left ventricular ejection fraction (LVEF) and cardiac troponin T (cTn T). Results There were significant differences in electrocardiogram (ECG) abnormality and LVEF between the two groups (P <0.05 ~ P <0.01) after the fourth cycle of chemotherapy. The difference of cTn T between the two groups after chemotherapy was statistically significant P <0.01). Conclusions Depridin has a protective effect on the cardiotoxicity induced by pirarubicin.