凋亡不同于坏死,是细胞自主的有序性死亡。最近的研究表明蛛网膜下腔出血后脑血管痉挛存在内皮细胞凋亡,而且痉挛血管壁的细胞凋亡在血管痉挛形成的机制中有重要的作用。凋亡受到多种相关基因的调控,这些基因已经被证实在痉挛血管壁组织中存在表达。延缓或阻止凋亡的发生和发展,有望为脑血管痉挛防治找到一条新的途径。 Apoptosis is different from necrosis and is a cell-autonomous and orderly death. Recent studies have shown that there is endothelial cell apoptosis in cerebral vasospasm after subarachnoid hemorrhage and that apoptosis in the spastic vessel wall plays an important role in the pathogenesis of vasospasm. Apoptosis is regulated by a variety of related genes that have been shown to be present in spastic vessel wall tissue. Delay or prevent the occurrence and development of apoptosis, is expected to find a new way for the prevention and treatment of cerebral vasospasm.