受传统的影响,以前人们一般不认为中枢神经系统有干细胞,这是因为人们长期形成的中枢神经系统不可再生的观念。1992年,Reynolds和Weiss从成年小鼠纹状体分离了能在体外不断分裂增殖,具有多种分化潜能的细胞群,并明确地提出了神经干细胞的概念。目前已经证实,这种具有自我更新、自我维持、多潜能的神经干细胞确实存在于发育中的神经系统,并 Traditionally, people generally do not think that there are stem cells in the central nervous system in the past because of the long-established concept that the central nervous system can not be regenerated. In 1992, Reynolds and Weiss isolated from adult mouse striatum cells capable of dividing and proliferating in vitro with multiple differentiation potential, and clearly put forward the concept of neural stem cells. It has been shown that this type of neural stem cell, which is self-renewing, self-sustaining and pluripotent, does exist in the developing nervous system