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目的:使用长托宁对急性重度有机磷农药中毒患者进行治疗,观察、分析临床治疗效果。方法:随机抽取我院自2010年3月-2014年10月收治的急性重度有机磷农药中毒患者共64例,其中治疗组患者32例使用长托宁进行治疗,对照组患者32例使用阿托品进行治疗。对两组患者的治疗后的症状、体征变化情况、心肌酶谱变化、全血胆碱酯酶活力水平进行对比、分析。结果:在对患者流涎、瞳孔变化、肺部啰音、出汗等症状和体征控制方面,两组患者之间没有明显的差异,P>0.05,达到阿托品化的时间为50-60分钟;胆碱酯酶恢复时间方面治疗组短于对照组;心肌酶谱变化:LDH、AST具有统计学意义上的明显差距,尤其是CK、CKMB差异极为明显。结论:使用阿托品对急性重度有机磷农药中毒患者进行抢救治疗,具有起效快、用药次数少、用量小、疗效确切、副作用少的特点,值得临床上推广使用。
Objective: The use of penehyclidine for acute severe organophosphorus pesticide poisoning in patients with treatment, observation, analysis of clinical treatment. Methods: A total of 64 patients with acute severe organophosphorus pesticide poisoning admitted to our hospital from March 2010 to October 2014 were randomly selected. Among them, 32 patients in the treatment group were treated with penehyclidine and 32 patients in the control group were treated with atropine treatment. After treatment of the two groups of patients with symptoms and signs, changes in myocardial enzymes, the level of whole blood cholinesterase activity were analyzed and compared. Results: There was no significant difference between the two groups in terms of patient salivation, pupil changes, pulmonary rales, sweating and other signs and symptoms. P> 0.05, the time to achieve atropisation was 50-60 minutes. The recovery time of esterase was shorter in the treatment group than in the control group. Changes in myocardial enzymes: LDH and AST were statistically significant differences, especially in CK and CKMB. Conclusion: The use of atropine for acute severe organophosphorus pesticide poisoning in patients with salvage treatment, with fast onset, less medication, dosage, exact effect, fewer side effects, it is worth promoting the clinical use.