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目的 :探讨口腔鳞癌患者化疗前、后血清可溶性白介素 2受体 (s IL - 2 R)水平的变化。方法 :用 EL ISA法动态检测 32例原发性口腔鳞癌患者化疗前、后血清 s IL - 2 R水平以及 30例正常人血清 s IL - 2 R水平。结果 :32例原发性口腔鳞癌患者治疗前血清 s IL - 2 R水平较正常人水平明显升高 (P <0 .0 0 1 ) ,化疗结束后患者血清 s IL - 2 R水平较化疗前水平明显下降 (P <0 .0 5 ) ,但仍高于正常人水平 (P <0 .0 1 )。其中 6例化疗无效患者血清 s IL - 2 R水平在化疗前后无明显变化 (P >0 .0 5 )。结论 :对口腔鳞癌患者化疗前后血清 s IL - 2 R水平的检测 ,可为临床化疗效果的评介提供客观依据
Objective: To investigate the changes of serum soluble interleukin - 2 receptor (sIL - 2R) level in patients with oral squamous cell carcinoma before and after chemotherapy. Methods: The levels of sIL - 2R and sIL - 2R in serum of 32 patients with primary oral squamous cell carcinoma were detected by ELISA before and after chemotherapy. Results: The serum level of sIL - 2R in 32 patients with primary oral squamous cell carcinoma was significantly higher than that in healthy people (P <0.01). The level of sIL - 2R in serum of patients with primary oral squamous cell carcinoma was significantly higher than that of chemotherapy Pre-level decreased significantly (P <0.05), but still higher than the normal level (P <0.01). Serum levels of sIL - 2R in 6 patients with chemotherapy ineffective had no significant changes before and after chemotherapy (P> 0.05). Conclusion: The detection of serum sIL - 2R levels in patients with oral squamous cell carcinoma before and after chemotherapy may provide an objective basis for the evaluation of the clinical effects of chemotherapy