一、绪言有关肝再生方面最早的比较有价值的材料要算是Von.Podwyssozki的研究,他在1886年就详细的描述了哺乳动物(猫、荷兰猪、家兔、大白鼠)肝再生的过程。他用各种局部损伤包括将肝切除一楔形小块的方法观察了被损伤部的再生过程,看到了在创伤表面有瘢痕形成,并有胆小管以生芽方式增生长入瘢痕组织然后变成肝细胞。至后Ponfick (1890)利用家兔和犬采取大块摘出肝脏组织的方法研究肝再生。他发现 I. INTRODUCTION The earliest, more valuable material for liver regeneration was the study of Von. Podwyssozki, who described in detail the process of liver regeneration in mammals (cats, dutch pigs, rabbits, rats) in 1886. He used a variety of local injuries, including the removal of a wedge resection of the liver was observed damaged part of the regeneration process, see the wound surface scar formation, and bile duct to grow into the scar tissue growth and then change Into hepatocytes. Later Ponfick (1890) studied the regeneration of the liver by taking large pieces of liver tissue from rabbits and dogs. He found