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目的 探讨乳腺癌导管内扩散与组织学分级、c -erbB -2过表达及脉管累犯的关系。方法 对 192例浸润性乳腺癌的导管内扩散情况及其与组织学分级、c -erbB -2过表达及脉管累犯的关系进行统计分析。结果 192例浸润性乳腺癌中 ,导管内扩散阳性 88例 (45 8% ) ;其中脉管累犯阳性组中 ,导管内扩散阳性率为 5 6 6% ,明显高于脉管累犯阴性组 (3 4 4% ) ,有显著差异 (P<0 0 5 )。导管内扩散阳性组中 ,c -erbB -2阳性率为 72 7% ,显著高于导管内扩散阴性组 (5 4 8% ,P <0 0 2 5 )。导管内扩散与组织学分级呈正相关 (P <0 0 5 )。结论 导管内扩散与组织学分级、c -erbB -2过表达及脉管累犯呈正相关 ,浸润性乳腺癌中伴导管内扩散者更具有侵袭性和转移性。
Objective To investigate the relationship between intraductal proliferation and histological grade, c-erbB-2 overexpression, and vascular recidivism in breast cancer. Methods The intraductal spread of 192 cases of invasive breast cancer and its relationship with histological grade, c-erbB-2 overexpression, and vascular recidivism were statistically analyzed. Results In 192 cases of invasive breast cancer, 88 cases (45 8%) were positive for intraductal proliferation, and the positive rate of intraductal diffusivity in the vasculature complication group was 56.6%, which was significantly higher than that of the vascular pleoplex group (3 4 4%), with significant difference (P<0 05). In the ductal positive group, the positive rate of c-erbB-2 was 72.7%, which was significantly higher than that in the ductal negative group (54.8%, P <00.25). Intraductal diffusion was positively correlated with histological grade (P < 0.05). Conclusion Intraductal spread is positively correlated with histological grade, c-erbB-2 overexpression, and vascular recidivism. Invasive breast cancer is more aggressive and metastatic in patients with intraductal spread.