目的:探析对不典型肺结核患者的临床诊断方式及鉴别诊断。方法:对笔者近年收治不典型结核患者临床资料以回顾性方式进行分析,归纳不典型结核患者临床诊断方式及其鉴别诊断内容。结果:不典型结核存在较为常见临床表现有肺结核中毒症状;其X线征象也有一定典型表现;需采取多种不同化验检查方法,确保对患者的诊断准确率。在检查过程中需重点与下列几种疾病相鉴别:非结核性炎症、空洞性病变、肿块型病变。结论:肺结核虽然已经有了治疗方法,但对其认识在部分地区依然存在不足,对于不典型肺结核患者不够重视,出现误诊漏诊从而错过最佳治疗时机,因此需要对该病有深入全面的认识,保障患者生命健康和生活质量。 Objective: To explore the clinical diagnosis and differential diagnosis of atypical pulmonary tuberculosis patients. Methods: The clinical data of patients with atypical tuberculosis in recent years were retrospectively analyzed, and the clinical diagnosis methods and their differential diagnosis of atypical tuberculosis patients were summarized. Results: Atypical tuberculosis has the more common clinical manifestations of tuberculosis symptoms; the X-ray signs also have some typical performance; need to take a variety of different laboratory tests to ensure that the diagnosis of patients with accuracy. In the inspection process to be focused on the following diseases and identification: non-tuberculous inflammation, empty lesions, mass lesions. CONCLUSIONS: Although the treatment of tuberculosis is already available, there are still some shortcomings in its cognition in some areas. It has not paid enough attention to patients with atypical pulmonary tuberculosis, misdiagnosis and missed diagnosis and thus missed the optimal timing of treatment. Therefore, it is necessary to have a thorough and comprehensive understanding of the disease, To protect the patient’s life and health and quality of life.