论文部分内容阅读
目的 探讨nm2 3基因表达与乳腺癌远处转移的关系及其预后意义。方法 选取两组共 16 9例乳腺癌患者 ,应用免疫组化和RT PCR方法检测nm2 3基因表达。结果 nm2 3基因表达与乳腺癌远处转移及腋淋巴结转移呈显著负相关 ,与生存率呈正相关。第 1组病例发生远处转移的 9例腋淋巴结阴性患者中 ,7例为nm2 3蛋白低表达 ;而 2 9例未发生远处转移的腋淋巴结阳性患者中 ,nm2 3蛋白中表达及高表达者为 2 4例 (82 .8% )。第 2组发生复发和远处转移的 6例患者其nm2 3mRNA均低表达。nm2 3基因表达与腋淋巴结转移、肿瘤大小均为影响预后的因素。结论 nm2 3基因作为一个独立的预后指标应用 ,可弥补常规指标的不足 ,具有重要的临床应用价值。
Objective To investigate the relationship between nm23 gene expression and distant metastasis in breast cancer and its prognostic significance. Methods Two hundred and nineteen breast cancer patients were selected and immunohistochemistry and RT PCR were used to detect the expression of nm23 gene. Results The expression of nm23 gene was significantly negatively correlated with distant metastasis and axillary lymph node metastasis in breast cancer, and positively correlated with survival rate. Among the 9 cases of axillary lymph node-negative patients with distant metastases in the first group of cases, 7 cases had low expression of nm23 protein, and in 29 cases with axillary lymph node metastasis without distant metastasis, the expression and high expression of nm23 protein were positive. There were 24 cases (82.8%). In the second group of patients with recurrence and distant metastasis, nm23 mRNA expression was low in 6 patients. Nm23 gene expression and axillary lymph node metastasis, tumor size are factors that affect the prognosis. Conclusions The application of nm23 as an independent prognostic indicator can compensate for the deficiency of conventional indicators and has important clinical application value.