维生素D缺乏世佝楼病是婴幼儿期常见的营养缺乏性疾病。骨碱性磷酸酶（BALP）作为一种早期诊断佝楼病的指标，具有较高灵敏度和特异性，已被广泛应用。近年来有关晚发性佝楼病和亚临床性佝楼病报道较多，常因症状不典型而贻误治疗，而膝关节和下肢疼痛作为儿小生长发育期常见的 Vitamin D deficiency Shiobu Lou disease is a common nutritional deficiencies in infancy and childhood diseases. Bone alkaline phosphatase (BALP) has been widely used as an indicator of early diagnosis of sparrow disease with high sensitivity and specificity. In recent years, there are more reports of late-onset Tau Lou disease and subclinical Tau Lou disease, often due to atypical symptoms and delaying treatment, while knee joint and lower limb pain are common as children’s growth and development