人类佐剂疾病(HAD)首先在1973年由 Miy-oshi 等提出,并认为它是一种类似于大鼠的佐剂关节炎的临床综合征。作者报告2例分别于注射硅酮隆起乳房成形术(隆乳术)及硅橡胶凝胶植入后,各自发生进行性系统性硬皮病样综合征。例1.女,60岁,因硬皮病于1986年6月就诊。1976年出现雷诺氏现象,1985年8月手及前臂,随后臂、胸上部及面部皮肤绷紧,进行性加重并伴轻度全身性瘙痒。前臂及下肢毛发脱落,出汗减少。1960年曾注射硅酮作双侧隆乳术。1978年因发热,右腋下淋巴结肿大、疼痛,遂切除该淋巴结。体检 Human adjuvant disease (HAD) was first proposed by Miy-oshi et al in 1973 and is considered to be a clinical syndrome similar to that of adjuvant arthritis in rats. The authors report two cases of progressive systemic scleroderma-like syndrome that occurred after injection of silicone augmentation breast augmentation (augmentation) and silicone rubber gel implants, respectively. Example 1. Female, 60 years old, due to scleroderma in June 1986 treatment. Raynaud’s phenomenon occurred in 1976, hands and forearms in August 1985, followed by tightening of the arms, chest and facial skin, progressive aggravation and mild systemic pruritus. Forearm and lower extremity hair loss, reduce sweating. 1960 injection of silicone for bilateral augmentation surgery. In 1978 due to fever, right axillary lymph nodes, pain, then remove the lymph nodes. Physical examination