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狼疮性肾炎(ｌｕｐｕｓｎｅｐｈｒｉｔｉｓ,ＬＮ)主要免疫异常特征是Ｂ细胞内源性多克隆激活而产生大量免疫球蛋白和自身抗体,Ｂ细胞过度激活的原因未明;另外,大剂量环磷酰胺静脉给药(ＩＶＣＴＸ)治疗ＬＮ在稳定肾功能、减少复发和改善预后等方面有独特疗效[1],但ＩＶＣＴＸ的
The main immunological abnormalities of lupus nephritis (LN) are the result of endogenous polyclonal activation of B cells resulting in a large number of immunoglobulins and autoantibodies. The reason for the excessive activation of B cells is unknown. In addition, intravenous administration of high dose cyclophosphamide IVCTX) in the treatment of LN has a unique effect in stabilizing renal function, reducing recurrence and improving prognosis [1], but IVCTX