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本文采用形态学观察及定量组织学技术分析了妊娠前后不同时间肌注碘油对仔鼠脑发育的影响。结果表明,低碘组(其母鼠末接受碘油)及孕晚注碘组(其母鼠于妊娠晚期接受碘油)生后日龄仔鼠发生体重、脑重明显减轻;大脑皮层厚度变薄,神经细胞密度增加,锥体细胞体积减小;小脑外颗粒层消失延迟以及浦氏细胞减小等变化。而母鼠于孕前,孕早期肌注碘油可以完全纠正缺碘对仔代脑发育所造成的影响。另外,实验中还发现孕晚注碘组仔鼠尽管于生后能从母乳中获得充足的碘供应,但对小脑的发育(主要在生后发育)却没有起到明显的保护作用。推测孕晚期肌注碘油可能对胎鼠甲状腺产生了抑制效应。
Morphological observation and quantitative histological techniques were used to analyze the effects of intramuscular lipiodol on the brain development of offspring rats at different times before and after pregnancy. The results showed that the body weight and brain weight of the pups in the low-iodine group (the end of the rats received lipiodol) and the iodine-injected group of the second trimester (pregnant rats received lipiodol in the third trimester) were significantly reduced. The changes of the cerebral cortex thickness Thinner, increased density of nerve cells, decreased volume of pyramidal cells, delayed disappearance of extragranular granular layer, and decrease of sobriety cells. The mothers before pregnancy, early pregnancy, intramuscular lipiodol can completely correct the impact of iodine deficiency on behalf of the generation of brain development. In addition, the experiment also found that pregnant rats injected with iodine in late pregnancy, although adequate after birth to obtain enough iodine supply from breast milk, but the development of the cerebellum (mainly in postnatal development) did not play a significant protective effect. It is speculated that intramuscular lipiodol in the third trimester may have inhibitory effects on the thyroid of fetus.