Aim: 2-bromopropane (2-BP) is known as an environmentalendocrine disrupter. Recently its reproductive and hematopoitic tox-icity has aroused the attention of the toxicologists. The presentstudy was designed to study its testicular toxicity in male rats.Methods; Forty male SD rats were divided into four groups of10 rats each. 2-BP was administered intraperitoneally at doses of1800 mg, 600 mg or 200 mg per kg body weight per day for 5days. The control rats were given a similar volume of the vehicle.The animals were sacrificed two days after the last dose. Results: With increasing doses, the seminiferous tubular damage wasgradually increased and the percentage of spermatogonia in the totalgerm cells gradually decreased ( P < 0. 05). The seminiferoustubular area of rats taking 1800 mg/kg was also reduced significant-ly . The body weight, testicular weight and relative testicular weightof rats taking the highest dose level were all significantly decreasedas compared with the controls. (Reprod Contracep 2001; Aim: 2-bromopropane (2-BP) is known as an environmentalendocrine disrupter. Recently its anctive and hematopoitic tox-icity has aroused the attention of the toxicologists. The present study was designed to study its testicular toxicity in male rats. Methods; Forty male SD rats were divided into four groups of 10 rats each. 2-BP was administered intraperitoneally at doses of 1800 mg, 600 mg or 200 mg per kg body weight per day for 5 days. The control rats were given a similar volume of the vehicle. were sacrificed two days after the last dose. Results: With increasing doses, the seminiferous tubular damage wasgradually increased and the percentage of spermatogonia in the total monthsm cells gradually decreased (P <0.05). The seminiferous tubular area of ​​rats taking 1800 mg / kg The body weight, testicular weight and relative testicular weightof rats taking the highest dose level were all significantly decreased as compared with the controls. (Repr od Contracep 2001;